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*Correspondence: Bassem Sadek, [email protected] This article was submitted to Neuropharmacology, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

In terms of mechanism, folate and vitamin B6/B12 can alleviate Hcy-induced ECs apoptosis, oxidative stress, and mitochondrial dysfunction (125), folate also can modulate DNA methylation to delay AS (126)

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Ironing out the details of ferroptosis